This is a really important Seth quote in terms of understanding the process of manifestation. What Seth calls Framework 2 I like to think of as the abstract space of all quantum possibilities from which we (along with the atoms and molecules, etc.) "Pop" moments of experience into a shared, 3-D, physical reality.
At sub-atomic scales, these associations are potential interactions of quanta of fields (e.g. electromagnetism, gravity, and strong and weak nuclear forces). Even the building blocks of time and space arise out of a sea of all possible interactions between potential quanta of space. For a really good, and very readable description of this, see Carlo Rovello's book on loop-quantum gravity: "Reality Is Not What It Seems". The very space that we think exists independent of us arises out of the "Framework 2" sea of all possibilities!
It is important to note that events appear in our private experience "according to directions you have given them through those associations that you form mentally". This is why "You Create Your Own Reality" (YCYOR)! To get a better idea of how the brain plays in this manifestation process I suggest you look at the Ramtha material, for example the book "Who Are We Really".
Lazaris tends to draw a distinction between coincidences and serendipities. Coincidences are quite common and generally don't have a lot of really deep significance or meaning ... they arise in the manner described here by Seth. Serendipities, on the other hand, arise when "souls are at play"! They can be life changing!
“Framework 2 deals with associations, so that within it the recognizable events of the physical world can be put together in an infinite number of ways, after which they appear in your private experience according to directions you have given them through those associations that you form mentally.
“The coincidences that seem to happen, the chance encounters, the unexpected events – all of these come into your experience because in one way or another you have attracted them, even though their occurrences might seem to have insurmountable odds against them. Those odds – those impediments – do not exist in Framework 2.”
(The Individual and the Nature of Mass Events, Session 825)